The F-35 is a fifth-generation weapon system with a range of operational capabilities that allow it to simultaneously and autonomously perform all missions in air tactician doctrine. The state-of-the-art technology applied to its onboard sensors and the aircraft's low observability (reduced capability of being detected by radar) increase its operational effectiveness, ensuring not only higher levels of survivability in hostile territories but also a high awareness and understanding of the tactical scenario.

The aircraft's advanced capabilities for discovery, identification, and engagement precision give it significant potential, which, combined with innovative communication and real-time sharing of essential information (Net-Centric capabilities), provides the pilot with unparalleled management of the operational theatre. The Italian Air Force possesses versions A, for Conventional Take-Off and Landing (CTOL), and B, for Short Take-Off and Vertical Landing (STOVL), for use on both austere runways and on assault ships, helicopter carriers, and aircraft carriers (LHA/LHD/CV). Italy is a Level II industrial partner and has the only Final Assembly and Check-Out (FACO) line in Europe at Cameri.